Shelley Li

First involved in the synthesis of N,N-diaryl pyrimidine-2,4-diamines to create structural analogs of the NNRTI, rilpivirine, using the Buchwald-Hartwig cross coupling reaction, I have since conducted a high throughput virtual screening and homology modeling of analogs of another NNRTI, efavirenz. In addition, I employed similar computational modeling efforts toward common tetracyclines to investigate their antibacterial properties and structure activity relationships. Finally, I’ve also been involved in the synthesis and biological testing of berberine analogs as a natural product pharmaceutical agent.